monoclonal antibody is the fastest growing biological product in recent years and currently occupies a leading position in all pharmaceutical markets in the world. Perinox has extensive experience in developing monoclonal antibodies and developing cost-effective production processes, including highly expressed cell lines, optimized media, and processes for improving downstream recovery and purification effects.

our experts have studied a variety of antibodies and pushed them to the market in many countries. We can construct new clones in CHO and NS0 cell lines, or we can start with client cell lines and improve their expression ability. We can use the platform process and a variety of processes and chromatography media for harvesting, separation and purification. Our experts have the most cost-effective purification technology, and we know how to get the best performance from a well-designed process.

In recent years, some standard monoclonal antibody substitutes have become products. Among them, bispecific antibodies have great application prospects in new products, especially in the treatment of cancer and other refractory diseases. For the successful expression and recovery of bispecific antibodies and other difficult-to-produce proteins, Baininox has extensive experience in process development.

antibody-coupled drugs are drugs that bind antibody-specific and specific toxic toxins, which are delivered to specific types of cells in the body. Although ADCs have the potential to provide a payload that can focus on specific types of cells (such as cancer cells), their development has been hindered by development and scale production challenges. Bainnoir is able to assist customers in bringing ADC products to market. We have the development and production capacity of all parts of ADC. We have experienced scientists who can develop production processes for highly specific antibodies. With the support of our partners, we can develop toxins and linkers that can destroy target cells while minimizing damage to neighboring cells. We have excellent production facilities to meet the commercial production of aseptic filling and meet the international cGMP standards. Bainino can develop ADC products from research platform to commercial production, which fully meets the international requirements of development, testing, identification and production.

For the production process of animal cell culture to produce a variety of recombinant proteins, Baininox's technical team has rich experience, such as monoclonal antibodies, bispecific antibodies, enzymes and other difficult-to-express proteins. We have studied many types of cells, such as CHO, NS0, stem cells, etc. We design efficient processes to maximize expression and recycling and minimize costs. Our factory is in

a single bioreactor has a production capacity of 50 liters to 6000 liters, our downstream processing is optimized to match the expression level range of these volumes. Our factory and quality system conform to Chinese and international cGMP standards.

Bainnoir facilities include gene therapy, plasmids, and cell therapy production units. Our plasmid unit includes 100L of fermentation, harvesting and isolation capabilities for the design and construction of various plasmids. The plasmid production area is isolated from other production development areas and has strict production control.

Our cell therapy production area includes multiple production units, which can effectively process patient samples used to produce allogeneic and autologous therapies. Our clean room meets the design and operation requirements of FDA and EMA in Europe. Baininox scientists have extensive experience in cell culture and commercial production.

Baininox gene therapy is produced in a dedicated clean room with strict air treatment and BSL-2 risk control procedures. Our scientists have extensive experience in virus culture, harvesting, isolation and detection.

Bainenol. We have professional filling and continuous chromatographic separation and purification equipment. The experience of our scientists and partners can be extended to many products and processes. We also have our own medium formulation and production team, which enables us to provide high yields at the lowest cost.